High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway
R. Ferretti, E. G. Moura, V. C. dos Santos, E. J. Caldeira, M. Conte, C. Y. Matsumura, A. Pertille, M. Mosqueira, N.A.
This study shows that high-fat diet reduces the beneficial effects of creatine supplementation on muscle function by inhibiting the IGF-PI3K-AKT-mTOR pathway in rats.
bioRxiv · Jun 14, 2018Physiology