Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment
R. Turpin, R. Liu, P. Munne, A. Peura, J. H. Rannikko, G. Philips, B. Boeckx, N. Salmelin, E. Hurskainen, I. Suleymanova, E. M. Vuorinen, L. Lehtinen, M. Mutka, P. E. Kovanen, L. Niinikoski, , J. Klefstrom
The paper uses a patient-derived explant model to show metformin enhances dendritic cell maturation by inhibiting complex I, improving anti-tumor immunity when combined with venetoclax.
bioRxiv · May 10, 2023Cancer Biology