Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis.
P. Melo, A. Pineros, C. H. Serezani
This study shows that macrophage-derived miR-21 promotes sepsis by repressing the PGE2/IL-10 axis, leading to increased glycolysis and inflammation.
bioRxiv · May 9, 2020Immunology