Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry
D. S. Roberts, M. Mann, B. H. Li, D. Kim, A. R. Brasier, S. Jin, Y. Ge
This study uses top-down mass spectrometry to analyze O-glycoform changes in the Omicron S-RBD variant compared to wild-type and Delta, revealing novel glycosites and structural heterogeneity.
bioRxiv · Feb 9, 2022Biochemistry