D. S. Roberts

Tumor Immune Cell Targeting Chimeras (TICTACs) reprogram tumor-associated macrophages

The paper develops TICTACs, which selectively target and degrade checkpoint receptors on tumor-associated macrophages without affecting other cells.

Mass spectrometry-based multi-omics identifies metabolic signatures of sarcopenia in rhesus monkey skeletal muscle

This study uses mass spectrometry-based multi-omics to identify metabolic signatures of sarcopenia in rhesus monkey skeletal muscle, revealing age-related changes in energy metabolism and muscle function.

Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics

This study develops a native nanoproteomics method to characterize the structure and dynamics of endogenous cardiac troponin complexes in human heart tissue using native top-down mass spectrometry.

Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics

This paper develops a top-down proteomics method to characterize endogenous phospholamban proteoforms in cardiac tissue, revealing site-specific PTMs.

High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms

This study develops a sensitive top-down proteomics method to analyze large proteoforms in single muscle cells, revealing heterogeneity and linking it to muscle fiber types.

One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant

This paper introduces a one-pot exosome proteomics method using a photocleavable surfactant, enabling rapid and effective exosomal lysis, protein extraction, and digestion, with high reproducibility and coverage.

Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry

This study uses top-down mass spectrometry to analyze O-glycoform changes in the Omicron S-RBD variant compared to wild-type and Delta, revealing novel glycosites and structural heterogeneity.

Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry

This study uses native top-down mass spectrometry to characterize O-glycoforms of the SARS-CoV-2 S-RBD, identifying seven glycoforms and their relative abundance.