P2X7 receptor signaling is not required but can enhance Th17 differentiation.
Y. Yang, M. E. Killeen, T. L. Sumpter, A. R. Mathers
This study shows that P2X7R on CD4+ T cells is necessary for Th17 differentiation but inhibits Th1 development, while P2X7R on dendritic cells enhances Th1 responses.
bioRxiv · Mar 19, 2021 · PreprintImmunology