Copper drives prion protein phase separation and modulates aggregation
M. J. Do Amaral, A. R. Passos, S. Mohapatra, T. S. L. Da Silva, R. S. Carvalho, M. d. S. Almeida, A. d. S. Pinheiro, S. Wegmann, Y. Cordeiro
This study shows copper promotes prion protein condensation and aggregation through oxidative stress and co-partitioning, suggesting a dual role in copper buffering and toxicity.
Science Advances · Nov 3, 2023Peer-reviewedBiophysics