S. Mohapatra

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

PTBP2 promotes cell survival and autophagy in Chronic Myeloid Leukemia by stabilizing BNIP3

This study shows PTBP2 stabilizes BNIP3 to promote cell survival and autophagy in CML, enhancing tumor formation and imatinib resistance.

Flock response to sustained asynchronous predator attacks

This study examines how flocks respond to multiple persistent predators using an agent-based model, finding that coordination strength and predator attack timing significantly affect prey survival.

Copper drives prion protein phase separation and modulates aggregation

This study shows copper promotes prion protein condensation and aggregation through oxidative stress and co-partitioning, suggesting a dual role in copper buffering and toxicity.

Analysis of root volatiles and functional characterization of a root-specific germacrene A synthase in Artemisia pallens

The paper identifies and functionally characterizes a root-specific terpene synthase in Artemisia pallens that produces major root volatiles.

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1

This study presents cryo-EM structures of C5aR1 bound to C5a and a synthetic peptide, revealing conformational changes and G-protein coupling mechanisms.

Massively parallel single molecule tracking of sequence-dependent DNA mismatch repair in vivo

The paper tracks DNA mismatch repair in E. coli using high-throughput sequencing and finds sequence-dependent repair efficiencies, with CC mismatches being poorly repaired and local context affecting TT, AG, and CT mismatches.

Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

This study identifies an evolutionarily conserved 'E-L-L' motif in the SARS-CoV-2 spike protein as a target for small molecule fusion inhibitors, showing posaconazole effectively blocks viral entry across variants.

NPEPPS is a novel and druggable driver of platinum resistance

This study identifies NPEPPS as a driver of cisplatin resistance in bladder cancer and shows its inhibition can enhance cisplatin efficacy in preclinical models.

Identification of QTLs for high grain yield and component traits in New Plant Types of rice

The paper identifies QTLs associated with grain yield and related traits in rice using SSR markers and association analysis.

Modified Pearson Correlation Coefficient for Two-color Imaging in Spherocylindrical Cells

The paper introduces a modified Pearson Correlation Coefficient (MPCC) to accurately assess correlation between two-color fluorescent images in spherocylindrical cells, addressing limitations of the standard PCC.