Localized oxygen control in a microfluidic osteochondral interface model recapitulates bone-cartilage crosstalk during osteoarthritis
L. J. Y. Ong, Z. Wang, A. R. Sun, J. Lee, I. Prasadam, Y.-C. Toh
This paper develops a microfluidic model with localized oxygen control to study osteoblast-chondrocyte interactions in osteoarthritis, showing differential oxygen environments alter signaling pathways and collagen expression.
bioRxiv · Nov 20, 2023 · PreprintBioengineering