Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine
Q. Wang, Y. Guo, A. R. Tam, R. Valdez, A. Gordon, L. Lihong, D. D. Ho
This study shows that the ancestral spike in bivalent COVID-19 vaccines causes deep immunological imprinting, limiting antibody breadth against Omicron subvariants.
bioRxiv · May 3, 2023Microbiology