Author

L. Lihong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 8 Approach:experimental assay· 7 Organism:human· 5 Assay:proteomics· 4 Assay:structural biology· 2 Organism:virus· 2 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

D. D. Ho· 8 shared Q. Wang· 4 shared A. Gordon· 3 shared R. Valdez· 3 shared Y. Guo· 3 shared A. Bowen· 2 shared G. Cerutti· 2 shared J. Gorman· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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8 shared papersMicrobiology

D. D. Ho

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

M. S. Piepenbrink, A. M. Khalil, A. Chang, A. Mostafa, M. Basu, S. Sarkar, S. Panjwani, Y. H. Ha, Y. Ma, C. Ye, Q. Wang, T. J. Green, J. L. Kizziah, N. B. Erdmann, P. A. Goepfert, , J. J. Kobie

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

bioRxiv · Apr 27, 2024 · PreprintImmunology

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

S. Turner, G. Amirthalingam, D. Bailey, D. H. Barouch, K. R. Bewley, K. Brown, Y. R. Cao, Y.-W. Chan, S. Charlton, DOVE consortium, N. S. Coombes, B. Hallis, D. D. Ho, F. Jian, N. Lasrado, , D. J. Smith

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

bioRxiv · Mar 27, 2024 · PreprintImmunology

SARS-CoV-2 Neutralizing Antibodies Following a Second BA.5 Bivalent Booster

Q. Wang, A. Bowen, J. Ho, R. Zhang, R. Valdez, E. Stoneman, A. Gordon, L. Lihong, D. D. Ho

This study evaluates the effect of a second BA.5 bivalent booster on SARS-CoV-2 neutralizing antibodies in elderly individuals, finding no significant increase in Omicron-specific titers after the second dose.

bioRxiv · Aug 13, 2023 · PreprintMicrobiology

Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine

Q. Wang, Y. Guo, A. R. Tam, R. Valdez, A. Gordon, L. Lihong, D. D. Ho

This study shows that the ancestral spike in bivalent COVID-19 vaccines causes deep immunological imprinting, limiting antibody breadth against Omicron subvariants.

bioRxiv · May 3, 2023Microbiology

Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot

Q. Wang, A. Bowen, R. Valdez, C. Gherasim, A. Gordon, L. Lihong, D. D. Ho

This study compares neutralizing antibody responses to bivalent and monovalent mRNA vaccines against SARS-CoV-2 variants, finding similar titers for bivalent vaccines against Omicron BA.4/BA.5 and ancestral strains.

bioRxiv · Oct 22, 2022 · PreprintMicrobiology

Structural basis for antibody resistance to SARS-CoV-2 omicron variant

G. Cerutti, Y. Guo, L. Lihong, Z. Zhang, L. Liu, Y. Luo, Y. Huang, H. H. Wang, D. D. Ho, Z. Sheng, L. Shapiro

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

bioRxiv · Dec 21, 2021 · PreprintImmunology

Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite

G. Cerutti, Y. Guo, T. Zhou, J. Gorman, M. Lee, M. Rapp, E. R. Reddem, J. Yu, F. Bahna, J. Bimela, Y. Huang, P. S. Katsamba, L. Lihong, M. S. Nair, R. Rawi, , L. Shapiro

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

bioRxiv · Jan 10, 2021Biochemistry

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

M. Lu, P. D. Uchil, W. Li, D. Zheng, D. S. Terry, J. Gorman, W. Shi, B. Zhang, T. Zhou, S. Ding, R. Gasser, J. Prevost, G. Beaudoin-Bussieres, S. P. Anand, A. Laumaea, , W. Mothes

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

bioRxiv · Sep 10, 2020Microbiology