Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer
H. Han, Y. Wang, J. N. Curto, S. Gurrapu, S. Laudato, A. Rumandla, G. Chakraborty, X. Wang, H. Chen, Y. Jiang, D. Kumar, E. G. Caggiano, B. Zhang, Y. Ji, S. N. Maity, , F. G. Giancotti
The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.
bioRxiv · Apr 14, 2021 · PreprintCancer Biology