Author

F. G. Giancotti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

D. Kumar· 3 shared H. Chen· 2 shared H. Han· 2 shared Y. Chen· 2 shared A. Aparicio· 1 shared A. D. Viny· 1 shared A. Rumandla· 1 shared B. Patel· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

D. Kumar

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer

S.-Y. Bae, H.-H. Ling, Y. Chen, H. Chen, D. Kumar, J. Zhang, A. D. Viny, R. A. DePinho, F. G. Giancotti

This study identifies Med4 as a regulator of metastatic dormancy in breast cancer, showing its role in maintaining chromatin structure and suppressing enhancer activation.

bioRxiv · Nov 18, 2023Cancer Biology

STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity

B. Patel, Y. Zhou, R. L. Babcock, F. Ma, M. A. Zal, D. Kumar, Y. B. Medik, L. M. Kahn, J. E. Pineda, E. M. Park, X. Tang, M. G. Raso, T. Zal, K. Clise-Dwyer, F. G. Giancotti, , S. S. Watowich

This study shows that STAT3 is essential for maintaining hematopoietic stem cell function by suppressing interferon signaling and myeloid skewing, and its loss leads to impaired hematopoietic activity.

bioRxiv · Feb 10, 2023 · PreprintImmunology

Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer

H. Han, Y. Wang, J. N. Curto, S. Gurrapu, S. Laudato, A. Rumandla, G. Chakraborty, X. Wang, H. Chen, Y. Jiang, D. Kumar, E. G. Caggiano, B. Zhang, Y. Ji, S. N. Maity, , F. G. Giancotti

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

bioRxiv · Apr 14, 2021 · PreprintCancer Biology

Prostate Epithelial Genes Define Docetaxel-Sensitive Prostate Cancer Molecular Subtype

H. Han, K. Choi, Y. J. Moon, J. E. Heo, W. S. Ham, W. S. Jang, K. H. Rha, N. H. Cho, F. G. Giancotti, Y. D. Choi

The paper identifies four molecular subtypes of prostate adenocarcinoma using transcriptomic data and links subtype B to docetaxel sensitivity and PSA/PAP ratio as a predictive biomarker.

bioRxiv · Aug 26, 2020Cancer Biology