Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end
J. M. Cleary, T. Kim, A. S. Cook, W. O. Hancock, L. M. Rice
The paper measures microtubule growth dynamics using interference reflection microscopy and models the effects of GTP hydrolysis, revealing that GDP exposure at the microtubule end increases growth fluctuations and suggests slow association kinetics.
bioRxiv · Nov 24, 2021 · PreprintCell Biology