Author

J. M. Cleary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Prosz· 2 shared H. Singh· 2 shared J.-B. Lazaro· 2 shared L. M. Rice· 2 shared N. S. Sethi· 2 shared P. Sahgal· 2 shared S. Spisak· 2 shared V. Tisza· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

A. Prosz

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Author profile →

5 papers

Recent·Most cited

Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends

L. A. McCormick, J. M. Cleary, W. O. Hancock, L. M. Rice

The paper resolves a debate on microtubule dynamics by showing that interfacial nucleotides determine tubulin:tubulin interaction strength through experimental and simulation studies.

bioRxiv · May 3, 2023Cell Biology

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

P. Sahgal, D. T. Patil, Z. Sztupinszki, V. Tisza, S. Spisak, B. Huffman, A. Prosz, H. Singh, J.-B. Lazaro, Z. Szallasi, J. M. Cleary, N. S. Sethi

The paper identifies DDR biomarkers and ploidy abnormalities in GEA that predict sensitivity to DDR inhibitors and premalignant progression.

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

A. Prosz, P. Sahgal, C. X. Morris, Z. Sztupinszki, J. Borcsok, M. Diossy, V. Tisza, S. Spisak, O. Rusz, I. Csabai, B. M. Huffman, H. Singh, J.-B. Lazaro, M. Cecchini, J. M. Cleary, , N. S. Sethi

This study identifies HR and NER deficiencies in gastric and esophageal adenocarcinomas and shows their responsiveness to platinum chemotherapy and PARP inhibitors.

bioRxiv · Jul 14, 2022 · PreprintCancer Biology

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

J. M. Cleary, T. Kim, A. S. Cook, W. O. Hancock, L. M. Rice

The paper measures microtubule growth dynamics using interference reflection microscopy and models the effects of GTP hydrolysis, revealing that GDP exposure at the microtubule end increases growth fluctuations and suggests slow association kinetics.

bioRxiv · Nov 24, 2021 · PreprintCell Biology

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

S. Raghavan, P. S. Winter, A. W. Navia, H. L. Williams, A. DenAdel, R. L. Kalekar, J. Galvez-Reyes, K. E. Lowder, N. Mulugeta, M. S. Raghavan, A. A. Borah, K. S. Kapner, S. A. Vayrynen, A. Dias Costa, R. W. S. Ng, , A. K. Shalek

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

bioRxiv · Aug 25, 2020 · PreprintCancer Biology