Author

A. S. Falk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

A. B. Siemer· 2 shared A. Rawat· 1 shared C. Hurd· 1 shared J. M. Bravo-Arredondo· 1 shared J. Varkey· 1 shared K. Ashami· 1 shared L. Ralf· 1 shared S. A. Cervantes Cortes· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

A. B. Siemer

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2 papers

Recent·Most cited

Droplet and fibril formation of the functional amyloid Orb2

K. Ashami, A. S. Falk, C. Hurd, S. Garg, S. A. Cervantes Cortes, A. Rawat, A. B. Siemer

This study shows that Orb2 can form protein droplets via LLPS, but these droplets rapidly mature into fibrils, suggesting phase separation initiates fibril formation.

bioRxiv · Feb 19, 2021Biophysics

Structural model of the proline-rich domain of huntingtin exon-1 fibrils

A. S. Falk, J. M. Bravo-Arredondo, J. Varkey, S. Pacheco, L. Ralf, A. B. Siemer

The paper models the conformational dynamics of the proline-rich domain (PRD) of huntingtin exon-1 fibrils using molecular dynamics simulations, validated by experimental data.

Biophysical Journal · Nov 1, 2020Peer-reviewedBiophysics