S. Garg

Heat pre-treatment reduces multiplicity of plasmid transformations in yeast during electroporation, without diminishing the transformation efficiency

The paper introduces a method to reduce plasmid transformation multiplicity in yeast during electroporation, improving mono-transformation rates without reducing efficiency.

Tuning of Chitosan with Lignin derived Bioactive Properties to develop a Lignin Reinforced and Sustainable Food Packaging Biomaterial

This paper develops a sustainable food packaging biomaterial by optimizing lignin from sugarcane tops to enhance chitosan hydrogel properties for improved bioactivity and mechanical performance.

Food Fermentation in Space Is Possible, Distinctive, and Beneficial

This study fermented miso on the International Space Station and found it is possible, with unique microbial and sensory characteristics compared to Earth-based controls.

Double Imprinted Nanoparticles for Sequential Membrane-to-Nuclear Drug Delivery

This study develops double imprinted nanoparticles for targeted drug delivery to breast cancer cells, showing enhanced toxicity in ER-positive cells and reduced side effects.

Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV-2 infection and pathogenesis

This study shows that inhibiting host Hsp70 reduces SARS-CoV-2 infection more effectively than Remdesivir by blocking viral entry and autophagy.

On-chip brain slice stimulation: precise control of electric fields and tissue orientation

This paper develops an on-chip platform for precise control of electric fields and tissue orientation in brain slice stimulation to better study the effects of direct current stimulation.

Increased response to immune checkpoint inhibitors with dietary methionine restriction

This study shows that dietary methionine restriction enhances immune checkpoint inhibitor efficacy in mice by increasing MHC-I and PD-L1 expression via the cGAS-STING pathway and interferon signaling.

Insights into the Interactions of Peptides with Monolayer-Protected Metal Nanoclusters

This study uses molecular dynamics simulations to examine how melittin interacts with gold-based MPCs, revealing hydrogen bonding and electrostatic interactions that stabilize the peptide on the nanocluster surface.

Droplet and fibril formation of the functional amyloid Orb2

This study shows that Orb2 can form protein droplets via LLPS, but these droplets rapidly mature into fibrils, suggesting phase separation initiates fibril formation.

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

Persistence of the ground beetle (Coleoptera: Carabidae) microbiome to diet manipulation

This study examines the microbiome of ground beetles across different diets and finds that soil environment, not diet, significantly affects bacterial diversity and composition.

Metalloprotease Gp63 targeting novel glycoside exhibits potential antileishmanial activity

This study identifies a glycoside derivative, Gly 2, with potent antileishmanial activity against Leishmania donovani, targeting the metalloprotease Gp63 and showing efficacy against both visceral leishmaniasis and post-kala-azar dermal leishmaniasis.

An equivalence of prokaryotic pore forming proteins of Plasmodium triggers cellular dysfunction responsible for malaria pathogenesis

This study shows that Plasmodium falciparum pore-forming proteins (PLPs) induce barrier cell dysfunction through necrotic cell death, contributing to severe malaria pathogenesis.

Quantifying Color Vision Changes Associated with Cataracts Using Cone Contrast Thresholds

This study quantifies color vision changes in cataract patients and aging individuals using cone contrast thresholds, finding age-related declines in S-cone sensitivity and improvements post-surgery.

Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion

The paper investigates how palmitoylation affects RBC membrane proteins and their role in Plasmodium falciparum invasion, finding that palmitoylation regulates receptor expression and susceptibility.

Mitochondria branch within Alphaproteobacteria

The paper investigates the phylogenetic placement of mitochondria within Alphaproteobacteria using alternative methods to address compositional heterogeneity.

Networks of enhancers and microRNAs drive variation in cell states

The paper identifies enhancers and microRNAs as drivers of cell state variation in embryonic stem cells, showing how they form feedback loops to generate new cell states.