Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells
A. Islam, Y.-C. Chang, X.-C. Chen, C.-W. Weng, C.-Y. Chen, C.-W. Wang, M.-K. Chen, A. S. Tikhomirov, A. E. Shchekotikhin, P. J. Chueh
This study identifies 4-dmH, a water-soluble heliomycin derivative, as more effective than parental heliomycin in oral cancer by targeting the tNOX-SIRT1 axis and inducing apoptosis.
bioRxiv · Mar 29, 2023Cell Biology