Y.-C. Chang

Live imaging of Alu elements reveals non-uniform euchromatin dynamics coupled to transcription

The paper uses CRISPR to live image Alu elements in euchromatin, revealing non-uniform dynamics linked to transcriptional activity.

Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

This study identifies 4-dmH, a water-soluble heliomycin derivative, as more effective than parental heliomycin in oral cancer by targeting the tNOX-SIRT1 axis and inducing apoptosis.

Condensate-driven interfacial forces reposition DNA loci and measure chromatin viscoelasticity

This paper introduces VECTOR, a method using light-inducible condensates to reposition DNA loci and measure chromatin viscoelasticity.

A di-arginine additive for dissociation of gold nanoparticle aggregates: A matrix-insensitive approach with applications in protease detection

This paper introduces a di-arginine additive for dissociating gold nanoparticle aggregates in complex matrices, enabling sensitive protease detection in biological fluids.

Dynamin-2 Phosphorylation as A Critical Regulatory Target of Bin1 and GSK3α for Endocytosis in Muscle

This study identifies Bin1 and GSK3α regulation of Dyn2 phosphorylation as critical for endocytosis in muscle, linking it to hereditary myopathy.

Precise control of microtubule disassembly in living cells

This study uses chemogenetics and optogenetics to precisely disassemble specific microtubule subtypes in living cells, revealing their roles in cellular processes.

Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants

This study reports cryo-EM structures of SARS-CoV-2 spike variants and finds mutations alter conformation and glycan shield, enhance ACE2 binding, but are neutralized by three antibodies.

Insulin Signaling Attenuates GLUT4 Endocytosis in Muscle Cells via GSK3a-Dyn2-Bin1 Interplay

This study identifies that insulin signaling reduces GLUT4 endocytosis in muscle cells by inhibiting Dyn2 activity through GSK3a-Bin1 interactions.

Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations

This study examines how B.1.1.7 mutations affect the structure and function of SARS-CoV-2 spike protein, showing changes in receptor binding and antibody neutralization.

COVID-19 dominant D614G mutation in the SARS-CoV-2 spike protein desensitizes its temperature-dependent denaturation

The paper shows the D614G mutation in SARS-CoV-2 spike protein increases thermal stability and reduces cold-induced unfolding, enhancing viral infectivity.

Intermittent KHz-frequency electrical stimulation selectively engages small unmyelinated vagal afferents

This study identifies intermittent KHz-frequency electrical stimulation (KES) as a method to selectively engage small unmyelinated vagal C-afferents in rats and mice.

Implant- and anesthesia-related factors affecting threshold intensities for vagus nerve stimulation

This study identifies implant- and anesthesia-related factors influencing threshold intensities for vagus nerve stimulation, showing neural thresholds are lower than physiological thresholds and that anesthesia type and implant age significantly affect these thresholds.

An implant for long-term cervical vagus nerve stimulation in mice

This paper develops a long-term vagus nerve stimulation implant in mice and demonstrates its effectiveness in reducing inflammation over 4 weeks.

Nucleated transcriptional condensates amplify gene expression

This study shows that TAF15 phase separation is enhanced by interactions with RNA Pol II CTD, lowering the energetic barrier for condensate formation and amplifying gene expression.

Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein

This paper introduces a sonogenetic method using an engineered auditory-sensing protein to control cellular activities with ultrasound, showing it can stimulate neurons in deep brain regions non-invasively.

TAO Kinase 3 Overexpression Is a Poor Prognosis Marker for Lung Adenocarcinoma and Predicts Paclitaxel Resistance

This study shows TAOK3 overexpression correlates with poor prognosis and paclitaxel resistance in lung adenocarcinoma, suggesting it as a therapeutic target.

Acute decrease in plasma membrane tension induces macropinocytosis via PLD2 activation

The paper shows that acute plasma membrane tension decrease triggers macropinocytosis through PLD2 activation and phosphatidic acid production in myoblasts.

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

The paper develops a method to rapidly deplete tubulin glutamylation in primary cilia, revealing its role in intraflagellar transport and Hedgehog signaling without affecting other PTMs.