PH Domain-Mediated Autoinhibition and Oncogenic Activation of Akt
H. Bae, T. Viennet, E. Park, N. Chu, A. Salguero, M. J. Eck, H. Arthanari, P. A. Cole
This study identifies a mutation in the PH domain of Akt that enhances autoinhibition and reveals the molecular mechanism of Akt activation as an oncogenic driver.
bioRxiv · May 25, 2022Biochemistry