Author

P. A. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Collard· 2 shared R. M. Alani· 2 shared A. Agrawal· 1 shared A. Brancale· 1 shared A. E. Carpenter· 1 shared A. Hanly· 1 shared A. Labadorf· 1 shared A. Salguero· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

M. Collard

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

R. Cao, O. Gozlan, L. Tveriakhina, H. Zhou, H. Jiang, P. A. Cole, J. C. Aster, D. Sprinzak, S. C. Blacklow

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

bioRxiv · Mar 1, 2024Biochemistry

p300 KAT regulates SOX10 stability and function in human melanoma

A. Waddell, N. Grbic, K. Leibowitz, W. A. Wyant, S. Choudhury, K. Park, M. Collard, P. A. Cole, R. M. Alani

This study identifies p300 KAT as a regulator of SOX10 stability and function in melanoma, showing that inhibiting p300 reduces SOX10 levels and melanoma proliferation and invasion.

bioRxiv · Feb 20, 2024Cancer Biology

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

J. L. Dahlin, B. K. Hua, B. E. Zucconi, S. D. Nelson, S. Singh, A. E. Carpenter, J. H. Shrimp, E. Lima-Fernandes, M. J. Wawer, L. P. Chung, A. Agrawal, M. O'Reilly, D. Barsyte-Lovejoy, M. Szewczyk, F. Li, , B. K. Wagner

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

bioRxiv · Jul 12, 2022 · PreprintPharmacology & Toxicology

PH Domain-Mediated Autoinhibition and Oncogenic Activation of Akt

H. Bae, T. Viennet, E. Park, N. Chu, A. Salguero, M. J. Eck, H. Arthanari, P. A. Cole

This study identifies a mutation in the PH domain of Akt that enhances autoinhibition and reveals the molecular mechanism of Akt activation as an oncogenic driver.

bioRxiv · May 25, 2022Biochemistry

The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

M. Wu, A. Hanly, F. Gibson, K. H. Kuang, J. Kalin, S. Nocco, M. Collard, M. W. Cole, A. Xiao, F. Agus, A. Labadorf, P. A. Cole, R. M. Alani

This study identifies the CoREST repressor complex as a mediator of melanoma phenotype switching and therapy resistance, showing that its inhibitor corin can reverse resistance to BRAF inhibitors.

bioRxiv · Sep 30, 2020Cancer Biology

Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.

G. Padalino, C. A. Celatka, H. Y. Rienhoff, J. H. Kalin, P. A. Cole, D. Lassalle, C. Grunau, I. W. Chalmers, A. Brancale, K. F. Hoffmann

This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology