Combination of NY-ESO-1-TCR-T-cells coengineered to secrete SiRPalpha decoys with anti-tumor antibodies to augment macrophage phagocytosis
E. Stefanidis, A. Semilietof, J. Pujol, B. Seijo, K. Scholten, V. Zoete, O. Michielin, R. Sandaltzopoulos, G. Coukos, M. Irving
This study combines NY-ESO-1 TCR-T cells secreting SiRPalpha decoys with anti-tumor antibodies to enhance macrophage phagocytosis and improve tumor control.
bioRxiv · Jun 27, 2023Bioengineering