V. Zoete

TCRfp: a new fingerprint-based approach for TCR repertoire analysis

This paper introduces TCRfp, a method converting TCR 3D structures into 1D fingerprints for high-throughput repertoire analysis and epitope recognition prediction.

A direct experimental test of Ohno's hypothesis

This study experimentally tests Ohno's hypothesis by evolving fluorescent protein genes in E. coli, finding that double-copy populations show increased mutational robustness and diversity but not accelerated phenotypic evolution.

Combination of NY-ESO-1-TCR-T-cells coengineered to secrete SiRPalpha decoys with anti-tumor antibodies to augment macrophage phagocytosis

This study combines NY-ESO-1 TCR-T cells secreting SiRPalpha decoys with anti-tumor antibodies to enhance macrophage phagocytosis and improve tumor control.

TCRpcDist: Estimating TCR physico-chemical similarity to analyze repertoires and predict specificities

TCRpcDist clusters TCR repertoires based on physico-chemical properties to predict antigen specificity and identify TCR groups likely to bind similar epitopes.

Rapid BCMA downmodulation on myeloma cells upon CAR T cell contact is mediated by trogocytosis and BCMA internalization

This study designs APRIL-based dual-antigen CAR T cells for multiple myeloma and finds rapid BCMA downmodulation on tumor cells through trogocytosis and internalization, independent of binding moiety.

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

The paper predicts MHC-II epitope specificities using machine learning, revealing a reverse binding mode in ligands across multiple species.

The actin assembly requirements of the formin Fus1 to build the fusion focus

This study investigates how the nucleation and elongation rates of the formin Fus1 affect the formation of the actin fusion focus in fission yeast, showing that native rates are optimal for this structure.