Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability
A. J. Sugarman, L. D. Huynh, A. Shabro, A. Di Cristofano
This study identifies upregulated mitochondrial one-carbon metabolism in anaplastic thyroid cancer as a targetable vulnerability, showing that inhibiting SHMT2 reduces proliferation and tumor growth.
bioRxiv · Apr 30, 2023Cancer Biology