Author

A. Sircar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

L. Sehgal· 2 shared A. Hart· 1 shared A. La Ferlita· 1 shared B. Soysal· 1 shared E. Chavdoula· 1 shared F. Choueiry· 1 shared G. Carota· 1 shared G. Nigita· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

L. Sehgal

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2 papers

Recent·Most cited

Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

E. Chavdoula, V. Anastas, A. La Ferlita, J. Aldana, G. Carota, M. Spampinato, B. Soysal, I. Cosentini, S. Parashar, A. Sircar, G. Nigita, L. Sehgal, M. A. Freitas, P. N. Tsichlis

This study identifies KDM2B's role in regulating amino acid metabolism through interactions with ncPRC1.1, MYC, and ATF4, revealing a metabolic network linked to poor prognosis in TNBC.

bioRxiv · Jul 7, 2023Cancer Biology

Multiomics Integration Elucidates Metabolic Modulators of Drug Resistance in Lymphoma

F. Choueiry, S. Singh, X. Sun, S. Zhang, A. Sircar, A. Hart, L. Alinari, N. Epperla, R. Baiocchi, J. Zhu, L. Sehgal

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.

bioRxiv · Jan 7, 2021 · PreprintCancer Biology