Author

G. Nigita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Canella· 2 shared E. R. Mardis· 2 shared P. Fadda· 2 shared P. Rajappa· 2 shared R. Distefano· 2 shared S. Rajendran· 2 shared A. Gross· 1 shared A. Haffey· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Canella

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4 papers

Recent·Most cited

Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

E. Chavdoula, V. Anastas, A. La Ferlita, J. Aldana, G. Carota, M. Spampinato, B. Soysal, I. Cosentini, S. Parashar, A. Sircar, G. Nigita, L. Sehgal, M. A. Freitas, P. N. Tsichlis

This study identifies KDM2B's role in regulating amino acid metabolism through interactions with ncPRC1.1, MYC, and ATF4, revealing a metabolic network linked to poor prognosis in TNBC.

bioRxiv · Jul 7, 2023Cancer Biology

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumormicroenvironment

A. Canella, M. Nazzaro, S. Rajendran, C. Schmitt, A. Haffey, G. Nigita, D. Thomas, H. Wrightnour, P. Fadda, E. R. Mardis, T. P. Cripe, P. Rajappa

This study shows that genetically modified myeloid cells releasing IL-2 can reprogram the glioma tumor microenvironment to enhance anti-tumor immunity in a mouse model.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

S. Rajendran, C. Peterson, A. Canella, Y. Hu, A. Gross, M. Cam, A. Serin Harmanci, R. Distefano, G. Nigita, W. Wang, K. E. Miller, O. Elemento, R. D. Roberts, E. C. Holland, G. Rao, , P. Rajappa

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

A concurrent canonical and modified miRNAome pan-cancer study on TCGA and TARGET cohorts leads to an enhanced resolution in cancer

R. Distefano, L. Tomasello, G. L. R. Vinciguerra, P. Gasparini, Y. Xiang, M. Bagnoli, G. P. Marceca, P. Fadda, A. Lagana, M. Acunzo, Q. Ma, G. Nigita, C. M. Croce

The paper analyzes miRNA modifications in cancer using TCGA and TARGET datasets, showing improved clustering and prognostic insights from combining canonical and modified miRNAs.

bioRxiv · May 18, 2021 · PreprintCancer Biology