Improved gene targeting in vivo using EoHR, a small molecule inhibitor of 53BP1
S. Spencer, F. O'Donoghue, A. Ristovski, A. Glaser, S. Maniam, M. Mohsenipour, A. Soch, A. J. Deans, S. Headey
This paper introduces EoHR, a 53BP1 inhibitor that enhances HDR efficiency in Cas9-mediated gene editing in mice, doubling successful edits and reducing time to project success.
bioRxiv · May 30, 2024 · PreprintBiochemistry