S. Spencer

Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

The paper develops an ingestible device to collect intestinal samples and identifies regional differences in microbiota and bile acids compared to stool.

Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

This study shows that nonhuman primates develop similar pulmonary scarring regardless of SARS-CoV-2 infection route, suggesting conserved disease mechanisms.

Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes

A 7-day homogeneous diet did not reduce interindividual variation in uremic microbiome-derived metabolites, indicating limited dietary impact and suggesting the need for microbial interventions.

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys

This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.

Culturing of "Unculturable" Subsurface Microbes: Natural Organic Carbon Source Fuels the Growth of Diverse and Distinct Bacteria from Groundwater

This study shows that complex natural organic carbon sources better enrich diverse subsurface bacteria than simple organic sources.

The use of CRISPR for variant specificity in the genetic diagnosis of primary immunodeficiency disease (PID)

The paper uses CRISPR to validate a specific IL-6R variant in primary human T lymphocytes as causative for PID, demonstrating its utility for assessing genetic defects in T lymphocytes.

Capturing the Diversity of Subsurface Microbiota - Choice of Carbon Source for Microcosm Enrichment and Isolation of Groundwater Bacteria

This study evaluates different carbon sources for enriching groundwater bacteria, finding that natural complex carbon sources enhance biodiversity compared to simple organic carbon sources.