A spatially regulated GTPase cycle of Rheb controls growth factor signaling to mTORC1
M. Kovacevic, C. H. Klein, L. Rossmannek, A. D. Konitsiotis, A. Stanoev, A. U. Kraemer, P. Bastiaens
The paper shows that spatial regulation of Rheb's GTPase cycle by PDE{delta} and Arl2-GTP controls mTORC1 activation in response to growth factors.
bioRxiv · Nov 16, 2018 · PreprintCell Biology