Author

C. H. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

P. Bastiaens· 2 shared A. D. Konitsiotis· 1 shared A. Stanoev· 1 shared A. U. Kraemer· 1 shared D. C. Truxius· 1 shared H. A. Vogel· 1 shared J. Harizanova· 1 shared L. Rossmannek· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

P. Bastiaens

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A spatially regulated GTPase cycle of Rheb controls growth factor signaling to mTORC1

M. Kovacevic, C. H. Klein, L. Rossmannek, A. D. Konitsiotis, A. Stanoev, A. U. Kraemer, P. Bastiaens

The paper shows that spatial regulation of Rheb's GTPase cycle by PDE{delta} and Arl2-GTP controls mTORC1 activation in response to growth factors.

bioRxiv · Nov 16, 2018 · PreprintCell Biology

PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas

C. H. Klein, D. C. Truxius, H. A. Vogel, J. Harizanova, S. Murarka, P. Martin-Gago, P. Bastiaens

This study shows that PDEδ inhibition specifically reduces proliferation and survival of colorectal cancer cells with oncogenic KRas mutations, but not those with wild-type KRas or other mutations.

bioRxiv · Jul 25, 2018Cell Biology