Author

A. Syeda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Organism:E. coli· 4 Assay:fluorescence / live-cell microscopy· 4 Research Focus:cell signaling & trafficking· 3 Approach:microscopy & imaging analysis· 3 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1

Frequent Co-Authors

M. C. Leake· 3 shared A. L. Payne-Dwyer· 2 shared J. W. Shepherd· 2 shared P. McGlynn· 2 shared A. Harvgreaves· 1 shared A. J. Wollman· 1 shared A. Leech· 1 shared A. Payne-Dwyer· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

M. C. Leake

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Author profile →

4 papers

Recent·Most cited

RecA and RecB: probing complexes of DNA repair proteins with mitomycin C in live Escherichia coli with single-molecule sensitivity

A. L. Payne-Dwyer, A. Syeda, J. W. Shepherd, L. Frame, M. C. Leake

This study uses super-resolved fluorescence microscopy to analyze RecA and RecB dynamics in live E. coli under DNA damage, revealing their spatial organization and stoichiometry changes.

bioRxiv · Oct 4, 2021Biophysics

Tetrameric UvrD helicase is located at the E. coli replisome due to frequent replication blocks

A. J. Wollman, A. Syeda, J. Howard, A. Payne-Dwyer, A. Leech, D. Warecka, C. Guy, P. McGlynn, M. Hawkins, M. C. Leake

The paper shows UvrD forms tetramers and associates with replication forks due to frequent nucleoprotein blocks, distinct from Rep's recruitment mechanism.

bioRxiv · Feb 22, 2021 · PreprintBiophysics

Combining single-molecule super-resolved localization microscopy with fluorescence polarization imaging to study cellular processes

J. W. Shepherd, A. L. Payne-Dwyer, J.-E. Lee, A. Syeda, M. C. Leake

This paper combines single-molecule super-resolved localization microscopy with fluorescence polarization imaging to simultaneously measure spatial location, molecular stoichiometry, and diffusion coefficients of tracked molecular complexes.

bioRxiv · Jan 6, 2021Biophysics

Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome

A. Syeda, A. Wollman, A. Harvgreaves, J. Bruning, P. McGlynn, M. Leake

The paper uses single-molecule live cell imaging to study the dynamic interactions of the bacterial helicase Rep with the replisome and PriC, revealing two distinct mechanisms for overcoming nucleoprotein barriers during DNA replication.

bioRxiv · Sep 29, 2018Biophysics