Cancer BiologybioRxiv
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer
J. Doffo, S. A. Bamopoulos, H. Kose…·M. Wirth
The paper identifies RUNX1 inhibition as a strategy to induce NOXA-dependent apoptosis in pancreatic cancer, showing it blocks tumor growth in vivo and in organoids.
DOI 10.1073/pnas.2105691119