The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion
A. Nasir, S. Camacho, A. T. McIntosh, G. T. Graham, R. Rahhal, M. E. Huysman, F. Alsharief, A. T. Riegel, G. W. Pearson
The paper identifies a Tgfβ-induced trailblazer population that integrates with Egfr signaling to promote collective invasion and shows this integration can be therapeutically targeted.
bioRxiv · Nov 14, 2020 · PreprintCancer Biology