Cell-free Trim-Away reveals the mechanism of antibody-mediated protein degradation by TRIM21
T. E. T. Mevissen, A. V. Prasad, J. C. Walter
The paper demonstrates that TRIM21-mediated antibody-dependent protein degradation (Trim-Away) requires target protein ubiquitination, not TRIM21, and establishes a cell-free system to study this process.
bioRxiv · Jul 23, 2022Biochemistry