Author

J. C. Walter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:Xenopus· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. A. Wu· 2 shared A. O. Gao· 1 shared A. S. Wang· 1 shared A. V. Prasad· 1 shared B. G. Gowen· 1 shared B. M. Stinson· 1 shared C. D. Richardson· 1 shared D. S. Pellman· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

R. A. Wu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining

B. M. Stinson, S. M. Carney, J. C. Walter, J. L. Loparo

This study identifies a structural role for DNA Ligase IV in promoting NHEJ fidelity by forming a short-range synaptic complex that enables rapid ligation of compatible DNA ends.

bioRxiv · Oct 26, 2022Biophysics

Cell-free Trim-Away reveals the mechanism of antibody-mediated protein degradation by TRIM21

T. E. T. Mevissen, A. V. Prasad, J. C. Walter

The paper demonstrates that TRIM21-mediated antibody-dependent protein degradation (Trim-Away) requires target protein ubiquitination, not TRIM21, and establishes a cell-free system to study this process.

bioRxiv · Jul 23, 2022Biochemistry

The histone chaperone FACT induces Cas9 multi-turnover behavior and modifies genome manipulation in human cells

A. S. Wang, L. Chen, R. A. Wu, C. D. Richardson, B. G. Gowen, K. R. Kazane, J. T. Vu, S. K. Wyman, J. Shin, J. C. Walter, J. Corn

This study identifies FACT as a factor that influences Cas9 turnover and genome editing efficiency in human cells.

bioRxiv · Jul 23, 2019Cell Biology

Mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements

L. Deng, R. A. Wu, O. V. Kochenova, D. S. Pellman, J. C. Walter

The paper shows mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements via TRAIP-dependent ubiquitylation of CMG helicase.

bioRxiv · Sep 26, 2018Biochemistry

The CMG helicase bypasses DNA protein cross-links to facilitate their repair

J. L. Sparks, A. O. Gao, M. Raschle, N. B. Larsen, M. Mann, J. P. Duxin, J. C. Walter

The paper shows that the CMG helicase bypasses DNA-protein cross-links without prior proteolysis, and RTEL1 aids this process and also promotes proteolysis.

bioRxiv · Jul 31, 2018Biochemistry