Inhibition of Parkinsons Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures
A. E. Leschziner, M. Sanz Murillo, A. V. Suarez, V. Dederer, D. Chatterjee, J. A. Louro, S. Knapp, S. Mathea
This study presents cryo-EM structures of LRRK2 bound to type-I and type-II inhibitors, revealing conformational changes and providing a basis for inhibitor design.
bioRxiv · Sep 7, 2023Biophysics