Author

V. Dederer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

S. Mathea· 3 shared A. E. Leschziner· 2 shared D. Chatterjee· 2 shared M. Sanz Murillo· 2 shared S. Knapp· 2 shared A. Pluckthun· 1 shared A. V. Suarez· 1 shared B. Dreier· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

S. Mathea

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

O. Raimi, H. Ojha, K. Ehses, V. Dederer, S. Lange, C. P. Rivera, T. Deegan, Y. Chen, M. Wightman, R. Toth, K. Labib, S. Mathea, N. Ranson, R. Fernandez-Busnadiego, M. Muqit

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

bioRxiv · Dec 23, 2023Biochemistry

Development of LRRK2 designed ankyrin-repeat proteins

V. Dederer, M. Sanz Murillo, E. P. Karasmanis, K. S. Hatch, D. Chatterjee, F. Preuss, K. R. Abdul Azeez, L. V. Nguyen, C. Galicia, B. Dreier, A. Pluckthun, W. Versees, S. Mathea, A. E. Leschziner, S. L. Reck-Peterson, S. Knapp

This study develops a high-affinity DARPin that binds to LRRK2's WD40 domain, improving structural analysis and revealing its role in disrupting LRRK2 filaments and Rab8A phosphorylation.

bioRxiv · Nov 14, 2023Biochemistry

Inhibition of Parkinsons Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

A. E. Leschziner, M. Sanz Murillo, A. V. Suarez, V. Dederer, D. Chatterjee, J. A. Louro, S. Knapp, S. Mathea

This study presents cryo-EM structures of LRRK2 bound to type-I and type-II inhibitors, revealing conformational changes and providing a basis for inhibitor design.

bioRxiv · Sep 7, 2023Biophysics