Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+ T cells in the tumor microenvironment and predicts clinical outcome in early- and late-phase clinical trials
A. Roller, I. I. Davydov, P. C. Schwalie, M. L. Serrano-Serrano, A. Heller, N. Staedler, C. S. Ferreira, G. Dietmann, I. Klaman, A. Valdeolivas, K. Korski, M. A. Cannarile
This study develops a transcriptome-based classifier to predict CD8+ T cell spatial infiltration patterns in the tumor microenvironment and shows its prognostic and predictive value across clinical trials.
bioRxiv · Oct 2, 2023Cancer Biology