Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
V. Janganati, P. Salazar, B. J. Parks, G. S. Gorman, P. L. Prather, E. C. Peterson, A. W. Alund, J. H. Moran, P. A. Crooks, L. K. Brents
This study shows that deuterated buprenorphine (BUP-D2) retains pharmacodynamic properties of buprenorphine and significantly reduces metabolism to the active metabolite norbuprenorphine in rats.
bioRxiv · Dec 12, 2022Pharmacology & Toxicology