Computational modeling predicts acidic microdomains in the glutamatergic synaptic cleft
Touhid Feghhi, Roberto X. Hernandez, Michał Stawarski, Connon I. Thomas, Naomi Kamasawa, A. W. C. Lau, Gregory Talisker Macleod
The paper models pH dynamics in the synaptic cleft of Drosophila NMJ, showing rapid acidification followed by prolonged alkalinization, resolving the discrepancy between ASIC activation and pH measurements.
Biophysical Journal · Nov 10, 2021Peer-reviewedNeuroscience