Connon I. Thomas

The paper identifies n-3 phosphatidylserines as a conserved neuronal lipotype dependent on dietary and lysosomal inputs, showing its role in synaptic function and circuit behavior.

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study shows that IpaC forms a translocation-competent pore essential for Shigella flexneri to escape double membrane vacuoles during intercellular spread.

The paper examines how astrocyte coverage of synapses in the ferret visual cortex correlates with synaptic structure and function, finding strong relationships between coverage and synaptic size, complexity, and functional properties.

This study shows that preventing NLGN1 cleavage increases synaptic vesicle docking and miniature currents in lateral amygdala synapses, revealing structural and functional roles of NLGN1 cleavage in native brain tissue.

The paper examines the positioning of mitochondria relative to dendritic spines in ferret visual cortex, finding no correlation with synaptic strength but instead suggesting a role in supporting diverse functional inputs.

This study shows that presynaptic Rac1 regulates synaptic strength by controlling synaptic vesicle priming and release probability in mouse calyx of Held synapses.

The paper shows that BK channels in small-headed dendritic spines reduce EPSP amplitude and enhance calcium signals, suggesting a role in synaptic regulation.

The paper investigates how binocular synaptic networks in visual cortical neurons contribute to interocular response alignment through functional and structural analysis.

The paper models pH dynamics in the synaptic cleft of Drosophila NMJ, showing rapid acidification followed by prolonged alkalinization, resolving the discrepancy between ASIC activation and pH measurements.

The paper challenges the Hebbian plasticity model by showing that cortical neuron selectivity arises from the total number of synapses, not strong individual inputs.

The paper investigates the role of CAST/ELKS in presynaptic development, finding reduced surface area and increased active zone size but no impairment in synaptic transmission.

The paper measures mitochondrial volume changes in calyx of Held synapses during development and finds increased mitochondrial volumes from postnatal day 7 to 21.