In Vitro Platform Establishes Antigen-Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition
Y. Li, A. W. Frei, E. Yang, I. Labrada-Miravet, C. Sun, Y. Rong, M. M. Samojlik, A. L. Bayer, C. L. Stabler
This paper establishes an in vitro platform to study CD8+ T cell cytotoxicity against encapsulated cells via indirect antigen recognition, revealing that hydrogel encapsulation blocks direct T cell activation but allows indirect activation through host APCs.
bioRxiv · Dec 11, 2019Bioengineering