E. Yang

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

Hierarchical design of pseudosymmetric protein nanoparticles

The paper designs large pseudosymmetric protein nanoparticles using a hierarchical computational method, achieving sizes up to 96 nm with 960 subunits.

Unraveling the dynamic transcriptomic changes during the dimorphic transition of Talaromyces marneffei through time-course analysis

This study identifies dynamic transcriptional changes during the dimorphic transition of Talaromyces marneffei using a novel model, DyGAM-NS, and reveals asymmetrical gene expression patterns and regulatory networks.

A multi-organ map of the human immune system across age, sex and ethnicity

The paper creates a comprehensive immune system map across age, sex, and ethnicity using single-cell RNA sequencing data, revealing immune ageing patterns and ethnic diversity in immune checkpoints.

FluoMALDI microscopy: matrix co-crystallization simultaneously enhances fluorescence and MALDI imaging

This paper introduces FluoMALDI microscopy, which enhances fluorescence and MALDI imaging by co-crystallizing fluorophores with MALDI matrices, enabling simultaneous high-resolution imaging of the same tissue sections.

Tumor-specific neutrophils originating from meninges promote glioblastoma

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

The paper uses MERFISH to analyze gene expression in a mouse colitis model, revealing fibroblast trajectories and spatial remodeling during inflammation.

RaMALDI: enabling simultaneous Raman and MALDI imaging of the same tissue section

This paper introduces RaMALDI, a method that combines Raman and MALDI imaging on a single tissue section to integrate molecular information from both modalities.

Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves

This study shows that corneal stromal stem cell secretome promotes scarless corneal wound healing and rescues sensory nerves by reducing inflammation, fibrosis, and complement-mediated cell death.

Substrate trapping approach identifies TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes

Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

This study shows rhamnan sulfate reduces atherosclerosis and vascular inflammation in ApoE-/- mice by enhancing endothelial barrier function and inhibiting NF-κB pathway activation.

Stem cell-free therapy for glaucoma to preserve vision

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

The paper isolates and characterizes cross-neutralizing antibodies from COVID-19 patients, identifying antibodies that neutralize both SARS-CoV-1 and SARS-CoV-2, including variants.

Enzyme engineering and in vivo testing of a formate-reduction pathway

The paper develops a 2-step formate-reduction pathway by screening and engineering enzymes, but finds no in vivo biomass assimilation despite in vitro activity.

The Cholesteryl Ester Transfer Protein (CETP) raises Cholesterol Levels in the Brain and affects Presenilin-mediated Gene Regulation.

This study shows CETP increases brain cholesterol and affects Alzheimer's-related gene regulation in mice.

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.

This study identifies the N-terminus of VZV glycoprotein B as critical for membrane fusion, showing that mutations in this region impair viral propagation.

In Vitro Platform Establishes Antigen-Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition

This paper establishes an in vitro platform to study CD8+ T cell cytotoxicity against encapsulated cells via indirect antigen recognition, revealing that hydrogel encapsulation blocks direct T cell activation but allows indirect activation through host APCs.

Elucidation of the determinant for orchestration of solo unisexual cycle in an important human fungal pathogen

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.