Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase
J. G. Beton, J. Monistrol, A. Wentink, E. C. Johnston, A. J. Roberts, B. Bukau, B. W. Hoogenboom, H. R. Saibil
The paper shows that Hsc70 and DNAJB1, with Apg2, cooperatively bind and disassemble amyloid fibrils, with Apg2 enhancing Hsc70 recruitment and disassembly rate.
bioRxiv · Aug 29, 2021Biochemistry