Author

A. J. Roberts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2 Animal Behavior & Cognition· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

A. G. Mukhopadhyay· 3 shared C. A. Moores· 2 shared C. Shak· 2 shared F. Shilliday· 2 shared L. Vuolo· 2 shared M. Roberto· 2 shared R. Tewari· 2 shared T. Liu· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCell Biology

A. G. Mukhopadhyay

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Roles for CEP170 in cilia function and dynein-2 assembly.

J. F. Weijman, L. Vuolo, C. Shak, A. Pugnetti, A. G. Mukhopadhyay, L. R. Hodgson, K. J. Heesom, A. J. Roberts, D. J. Stephens

This study identifies CEP170 as a protein interacting with dynein-2, showing its role in dynein-2 assembly and cilia function through effects on intraflagellar transport and Hedgehog signaling.

bioRxiv · Nov 20, 2023Cell Biology

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

C. Shak, L. Vuolo, B. Uddin, Y. Katoh, T. Brown, A. G. Mukhopadhyay, K. Heesom, N. Stevenson, A. J. Roberts, K. Nakayama, D. Stephens

The study examines how disease-associated WDR34 mutations affect cilia assembly and function in a knockout cell model, revealing diverse phenotypic impacts.

Journal of Cell Science · Nov 7, 2022Peer-reviewedCell Biology

IFT-A Structure Reveals Carriages for Membrane Protein Transport into Cilia

S. J. Hesketh, A. G. Mukhopadhyay, D. Nakamura, K. Toropova, A. J. Roberts

The paper determines the structure of the human IFT-A complex using cryo-EM and shows its role in membrane protein transport into cilia via interactions with TULP adaptors.

bioRxiv · Aug 9, 2022Cell Biology

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

C.-k. Oh, T. Nakamura, N. Beutler, X. Zhang, J. Pina-Crespo, M. Talantova, S. Ghatak, D. Trudler, L. N. Carnevale, S. R. McKercher, M. A. Bakowski, J. K. Diedrich, A. J. Roberts, A. K. Woods, V. Chi, , S. A. Lipton

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

bioRxiv · Apr 5, 2022Microbiology

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

T. Liu, F. Shilliday, A. D. Cook, R. Tewari, C. J. Sutherland, A. J. Roberts, C. A. Moores

This study investigates the molecular mechanism of Plasmodium kinesin-8B, showing its role in male gamete development and parasite transmission through ATP-dependent microtubule interactions and structural adaptations.

bioRxiv · Feb 11, 2022Biochemistry

Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase

J. G. Beton, J. Monistrol, A. Wentink, E. C. Johnston, A. J. Roberts, B. Bukau, B. W. Hoogenboom, H. R. Saibil

The paper shows that Hsc70 and DNAJB1, with Apg2, cooperatively bind and disassemble amyloid fibrils, with Apg2 enhancing Hsc70 recruitment and disassembly rate.

bioRxiv · Aug 29, 2021Biochemistry

The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation

K. B. Grigsby, R. A. Mangieri, A. J. Roberts, M. J. Lopez, A. Tran, E. J. Firsick, K. G. Townsley, A. Beneze, J. Bess, T. K. Eisenstein, J. J. Meissler, J. M. Light, J. Miller, S. Quello, F. Shadan, , A. R. Ozburn

This study shows that the FDA-approved drug apremilast reduces excessive alcohol drinking in both preclinical models and human studies.

bioRxiv · May 13, 2021 · PreprintAnimal Behavior & Cognition

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice

K. Frank, S. Abeynaike, R. Nikzad, R. R. Patel, A. J. Roberts, M. Roberto, S. Paust

This study shows that chronic alcohol exposure in mice increases systemic IFN-γ and IL-17 responses in a cell and organ-specific manner.

bioRxiv · Sep 3, 2020Immunology

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

M. Zeeshan, F. Shilliday, T. Liu, S. Abel, T. Mourier, D. J. P. Ferguson, E. Rea, R. R. Stanway, M. Roques, D. Williams, E. Daniel, D. Brady, A. J. Roberts, A. A. Holder, A. Pain, , R. Tewari

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

bioRxiv · Jun 29, 2019Cell Biology