A. Wignall

The Oral Bioavailability of Lurasidone is Impacted by Changes to the Gut Microbiome: Implications for Antipsychotic Therapy

This study shows that gut microbiome changes affect lurasidone bioavailability in rats, with prebiotics increasing it 4.3-fold and antibiotics reducing it in 80% of animals.

The atypical antipsychotic lurasidone positively modulates the gut microbiota in rats: A comparative study to olanzapine

This study compares the effects of olanzapine and lurasidone on gut microbiota in rats, finding lurasidone increases microbial diversity and richness without metabolic dysfunction, while olanzapine reduces diversity and causes metabolic issues.