K. Collins

Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice

This study shows that reduced CB1 receptor function in GABAergic neurons of FXS model mice rescues cortical hyperexcitability and sensory-driven synchrony deficits.

The Oral Bioavailability of Lurasidone is Impacted by Changes to the Gut Microbiome: Implications for Antipsychotic Therapy

This study shows that gut microbiome changes affect lurasidone bioavailability in rats, with prebiotics increasing it 4.3-fold and antibiotics reducing it in 80% of animals.

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs

This study shows that gammaherpesvirus infection leads to tRNA cleavage, producing tRNA fragments that are regulated by tRNA splicing factors and essential for viral replication.

The atypical antipsychotic lurasidone positively modulates the gut microbiota in rats: A comparative study to olanzapine

This study compares the effects of olanzapine and lurasidone on gut microbiota in rats, finding lurasidone increases microbial diversity and richness without metabolic dysfunction, while olanzapine reduces diversity and causes metabolic issues.

Human Soluble Prorenin Receptor Expressed in Adipose Tissue Improves Insulin Sensitivity and Endothelial Function in Obese Female Mice

This study shows that human sPRR expressed in adipose tissue improves insulin sensitivity and endothelial function in obese female mice, but not in males.

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

The paper quantifies sporozoite expulsion from Anopheles mosquitoes infected with P. falciparum gametocytes, finding that infection burden correlates with sporozoite expulsion.

Nanopore molecular trajectories of a eukaryotic reverse transcriptase reveal a long-range RNA structure sensing mechanism

The paper uses nanopore sequencing to study the single-nucleotide kinetics of a reverse transcriptase, revealing its ability to sense and destabilize RNA structures during cDNA synthesis.

Low-bias ncRNA Libraries using Ordered Two-Template Relay: Serial Template Jumping by a Modified Retroelement Reverse Transcriptase

This paper develops OTTR, a low-bias RNA sequencing method using retroelement RTs, outperforming commercial kits and enabling comprehensive ncRNA inventories.

Reevaluation of the RNA binding properties of the Tetrahymena thermophila telomerase reverse transcriptase N-terminal domain

The paper reevaluates the RNA binding properties of the Tetrahymena thermophila TERT TEN domain and finds that it binds RNAs based on length rather than sequence due to contamination in previous studies.

Gene Therapy for Follistatin Mitigates Systemic Metabolic Inflammation and Post-Traumatic Osteoarthritis in High-Fat Diet-Induced Obese Mice

This study shows that FST gene therapy reduces metabolic inflammation and post-traumatic OA in obese mice by improving mitochondrial function and adipose tissue browning.