In-vitro Modeling of Intravenous Drug Precipitation by the Optical Spatial Precipitation Analyzer (OSPREY)
A. J. Radosevich, R. L. Martin, W. R. Buck, L. Hicks, A. Wilsey, J. Y. Pan
This paper introduces OSPREY, an in-vitro flow-through system that quantifies precipitation of small molecule therapeutics in whole blood, validating its performance with microspheres and a tool compound.
bioRxiv · Mar 2, 2023Pharmacology & Toxicology