Author

A. J. Radosevich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Assay:metabolomics· 3 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

F. Pu· 4 shared J. D. Williams· 4 shared N. L. Elsen· 4 shared J. W. Sawicki· 3 shared D. Chang-Yen· 2 shared J. Y. Pan· 2 shared N. N. Talaty· 2 shared S. M. Gopalakrishnan· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiochemistry

F. Pu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolite Fingerprinting for Phenotypic Screening by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

A. N. Joignant, F. Pu, S. M. McLoughlin, J. W. Sawicki, A. J. Radosevich, R. Ma, J. D. Williams, S. M. Gopalakrishnan, N. L. Elsen

This paper demonstrates a high-throughput phenotypic screening method using IR-MALDESI mass spectrometry to identify glutaminase inhibitors and distinguish them from nuisance compounds.

bioRxiv · Dec 20, 2023Cell Biology

In-vitro Modeling of Intravenous Drug Precipitation by the Optical Spatial Precipitation Analyzer (OSPREY)

A. J. Radosevich, R. L. Martin, W. R. Buck, L. Hicks, A. Wilsey, J. Y. Pan

This paper introduces OSPREY, an in-vitro flow-through system that quantifies precipitation of small molecule therapeutics in whole blood, validating its performance with microspheres and a tool compound.

bioRxiv · Mar 2, 2023Pharmacology & Toxicology

A New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

F. Pu, A. J. Radosevich, B. G. Bruckner, D. A. Fontaine, S. C. Panchal, J. D. Williams, S. M. Gopalakrishnan, N. L. Elsen

This paper introduces a high-throughput label-free cellular pharmacodynamic assay using IR-MALDESI to identify glutaminase inhibitors and confirm hits with mass spectrometry-based assays.

bioRxiv · Jan 30, 2023Biochemistry

High Throughput Intact Protein Analysis for Drug Discovery Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

F. Pu, S. A. Ugrin, A. J. Radosevich, D. Chang-Yen, J. W. Sawicki, N. N. Talaty, N. L. Elsen, J. D. Williams

This paper demonstrates the use of IR-MALDESI-MS for high throughput intact protein analysis in drug discovery, achieving faster sample rates than traditional ESI-MS methods.

bioRxiv · Nov 8, 2021Biochemistry

Ultrahigh-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

A. J. Radosevich, F. Pu, D. Chang-Yen, J. W. Sawicki, N. N. Talaty, N. L. Elsen, J. D. Williams, J. Y. Pan

This paper develops an ultrahigh-throughput IR-MALDESI mass spectrometry method capable of analyzing 22 samples per second with low carryover and high repeatability.

bioRxiv · Oct 25, 2021 · PreprintPharmacology & Toxicology