A. Z. Schwartz

ZIF-1-mediated degradation of endogenous and heterologous zinc finger proteins in the C. elegans germ line

The paper demonstrates that ZIF-1 can degrade ZF1-tagged proteins in C. elegans germ cells, enabling conditional protein depletion to study germ line development.

Germline TFAM levels regulate mitochondrial DNA copy number and mutant heteroplasmy in C. elegans

This study shows that increasing TFAM levels in C. elegans germ line increases mtDNA copy number and mutant heteroplasmy.

Independent regulation of mtDNA quantity and quality resets the mitochondrial genome in C. elegans primordial germ cells

The paper shows that C. elegans primordial germ cells use separate mechanisms to control mtDNA quantity and quality, resetting the mitochondrial genome.